Caniggia Lab

1. Alahari, S. et al. Fibronectin and JMJD6 signature in circulating placental extracellular vesicles for the detection of preeclampsia. Endocrinology 164, (2023).

2. Klemetti, M. M., Alahari, S., Post, M. and Caniggia, I. Distinct changes in placental ceramide metabolism characterize type 1 and 2 diabetic pregnancies with fetal Macrosomia or preeclampsia. Biomedicines 11, 932 (2023).

1. Gillmore, T. et al. Dichotomy in hypoxia-induced mitochondrial fission in placental mesenchymal cells during development and preeclampsia: Consequences for trophoblast mitochondrial homeostasis. Cell Death and Disease 13, (2022).

2. Sallais, J. et al. HIF1 inhibitor Acriflavine rescues early-onset preeclampsia phenotype in mice lacking placental prolyl hydroxylase domain protein 2. JCI Insight 7, (2022).

1. Alahari, S. et al. JMJD6 dysfunction due to iron deficiency in preeclampsia disrupts fibronectin homeostasis resulting in diminished trophoblast migration. Frontiers in Cell and Developmental Biology 9, (2021).

2. Ermini, L. et al. Ceramide-induced lysosomal biogenesis and exocytosis in early-onset preeclampsia promotes exosomal release of SMPD1 causing endothelial dysfunction. Frontiers in Cell and Developmental Biology 9, (2021).

1. Abbade, J. et al. Increased placental mitochondrial fusion in gestational diabetes mellitus: An adaptive mechanism to optimize feto-placental metabolic homeostasis? BMJ Open Diabetes Research and Care 8, (2020).

1. Farrell, A. et al. Faulty oxygen sensing disrupts angiomotin function in trophoblast cell migration and predisposes to preeclampsia. JCI Insight 4, (2019).

1. Alahari, S., Garcia, J., Post, M. and Caniggia, I. The von hippel lindau tumour suppressor gene is a novel target of E2F4-mediated transcriptional repression in preeclampsia. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864, 3298–3308 (2018).

2. Alahari, S., Post, M., Rolfo, A., Weksberg, R. and Caniggia, I. Compromised JMJD6 histone demethylase activity affects VHL gene repression in preeclampsia. The Journal of Clinical Endocrinology and Metabolism 103, 1545–1557 (2018).

3. Ausman, J. et al. Ceramide-induced bok promotes mitochondrial fission in preeclampsia. Cell Death and Disease 9, (2018).

1. Bailey, L. J., Alahari, S., Tagliaferro, A., Post, M. and Caniggia, I. Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis. Cell Death and Disease 8, (2017).

2. Caniggia, I., Post, M. and Ermini, L. Statins, mevalonate pathway and its intermediate products in placental development and preeclampsia. Current Molecular Pharmacology 10, 152–160 (2017).

3. Ermini, L. et al. A single sphingomyelin species promotes exosomal release of endoglin into the maternal circulation in preeclampsia. Scientific Reports 7, (2017).

4. Sallais, J. et al. Factor inhibiting HIF1-a novel target of SUMOylation in the human placenta. Oncotarget 8, 114002–114018 (2017).

1. Bhattacharjee, J. et al. Dynamic regulation of HIF1Α Stability by SUMO2/3 and SENP3 in the human placenta. Placenta 40, 8–17 (2016).

2. Xu, J. et al. Aberrant TGFΒ signaling contributes to altered trophoblast differentiation in preeclampsia. Endocrinology 157, 883–899 (2016).

1. Alahari, S., Post, M. and Caniggia, I. Jumonji domain containing protein 6: A novel Oxygen sensor in the human placenta. Endocrinology 156, 3012–3025 (2015).

2. Chauvin, S. et al. Aberrant TGFΒ signalling contributes to dysregulation of sphingolipid metabolism in intrauterine growth restriction. The Journal of Clinical Endocrinology and Metabolism 100, (2015).

3. Melland-Smith, M. et al. Disruption of sphingolipid metabolism augments ceramide-induced autophagy in preeclampsia. Autophagy 11, 653–669 (2015).

1. Kalkat, M. et al. Placental autophagy regulation by the bok-MCL1 rheostat. Autophagy 9, 2140–2153 (2013).

2. Nevo, O., Lee, D. K. and Caniggia, I. Attenuation of VEGFR-2 expression by sFlt-1 and low oxygen in human placenta. PLoS ONE 8, (2013).

3. Sivasubramaniyam, T. et al. Where polarity meets fusion: Role of Par6 in trophoblast differentiation during placental development and preeclampsia. Endocrinology 154, 1296–1309 (2013).